- Species: Human (Homo Sapiens Sapiens)
- Gender: Female
- Alignment: Evil
The large Madame Amberly (voiced by Susan Silo) runs the Academy of Evil. She was once Dr. Neo Cortex's teacher back when he was a kid (whom she would often call a crybaby), and her dislike for him has persisted even during his adult years. She has the ability to generate electricity and won't stop at anything, so don't get in her way unless you want to be put in detention.